Pluronic F-127 gel is a polaxamer with helpful as well as interesting physical characteristics. This gel is of particular consideration because it is able to perform as a carrier of drugs for absorption through the skin. For instance, say there is a patient that is unable to tolerate anti-inflammatory medications because of ulcers or stomach upset. This medication can be added to this topical absorbing vehicle and bypass this side effect.
Currently our pain management physicians use these delivery systems for a wide variety of drugs with arthritis, fibromyalgia, and neuropathic pain and osteoporosis patients.
Patients apply the gel on the wrist or stomach for fast absorption. They may also use this gel directly on the joint or point of pain.
An example of this gel is Ketoprofen PLO. This is a topical non-steroidal anti-inflammatory drug that reduces pain and inflammation. Unlike oral Ketoprofen, Ibuprofen and Naproxen, topical applications of Ketoprofen produces less (some reports say none) GI ulcerations, erosions and other side effects (the number one side effect of the other NSAIDS such as Ibuprofen). NSAIDS are the drugs of choice for bone pain, muscle pain, and burns, but the gastric side-effects often limit the use of regular orally prescribed medications. It has been demonstrated that topical Ketoprofen concentrates at the site where administered; it can be found in higher concentrations in the synovial fluid, synovial capsule and underlying tissue than in the plasma. So instead of taking large amounts of oral NSAIDS to circulate throughout the entire body, you can instead apply Ketoprofen Organogel directly to the site of pain, and have higher levels of active drug at that site with few, if any, side effects. Ketoprofen as a topical gel is well known and well used in Europe and Canada, but has not made the transition to the United States, except for now at S&P; Prescription Compounding Services of Long Island.
Along with anti-inflammatory medications we also add muscle relaxants (Flexeril, Baclofen), anesthetics and neuropathic pain medications (e.g. Amitriptyline, clonidine and gabapentin). Our clients that use these gels do feel the difference and have an improved pain scale rating while on this transdermal system. Some of them have reduced or even discontinued their orally prescribed pain medications.
If anyone is interested in finding a pain care physician who utilizes this therapy please contact S&P; Prescription Compounding Services at SFerzola@hotmail.com or call us a 516-644-2470. We will be happy to refer you to a superior pain physician.
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