Drug nanocarriers framed of natural (chitosan, C) or synthetic polymers (polylactide co-glycolide, PLGA) show ameliorated drug features, efficacy and reduction in toxicity C-PLGA nanoparticles (110 nm) were synthesised by coacervation method and laded with FLZ, achieving ~8-wt% drug loading. Organic raw materials displayed pH-tuned slow sustained drug release (83 %) up to 5 d, at pH&