It is for that reason that Cumyl-PINACA and never its fluorinated analog was used for further experiments. A controlled self-experiment with one volunteer ingesting a low dose of Cumyl-PINACA orally was carried out to investigate its in vivo phase I metabolism. Incidentally, it has been reported that tert-leucinate-type cannabinoids, similar to 5-fluoro ADB, are stronger agonists of CB1 and C
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