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Kawasaki Disease Awareness Day is January 26

Awareness and prompt treatment of little-known disease saves lives. Early diagnosis of Kawasaki Disease is critical, but the illness is too often missed.

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A group of dedicated parents and former patients is seeking to raise awareness of a mysterious illness that comes on suddenly, usually strikes the very young and causes a host of unusual symptoms that can make a child miserable. Kawasaki Disease (KD) is a little-known illness that can lead to permanent heart damage or even take a young life if not diagnosed and treated in a timely manner.

Awareness of symptoms on the part of parents, prompt diagnosis and early treatment can save lives and prevent future health problems. To that end, the Kawasaki Disease Foundation has declared January 26, 2011 the first annual National Kawasaki Disease Awareness Day.

"We chose this date because on January 26, 1961, Dr. Tomisaku Kawasaki of Japan saw his second patient with the telltale signs of what would later be named Kawasaki Disease," said Greg Chin, president of the KD Foundation. "Fifty years later, we know it is the No.1 cause of acquired heart disease in children. But early diagnosis and prompt treatment can prevent the complications of Kawasaki Disease. That's why we want parents to recognize the signs and take their child to the doctor immediately if he or she has persistent fever and other symptoms," said Mr. Chin, whose son had the disease, but fully recovered.

Kawasaki Disease involves an inflammation of blood vessels throughout the body. More than 80 percent of patients are under age five, although older children and teenagers can also get KD. The hallmark of the disease is a fever that lasts for several days. Other early signs include a rash (often worse in the groin area); very red eyes, without drainage or crusting; bright red, swollen, cracked lips; "strawberry tongue", which appears with shiny bright red spots after the top coating sloughs off; swollen hands and feet; redness of the palms and soles of the feet; and swollen lymph nodes in the neck. Most children are extremely irritable.

"Unfortunately, untreated Kawasaki Disease can cause serious problems later in life," according to Jane C. Burns, MD, director of the Kawasaki Disease Research Center at Rady Children's Hospital and the University of California San Diego. The Research Center began an adult Kawasaki Disease study in 2009 to address a surprising number of reported cases of young adults suffering heart attacks in their early twenties and thirties as a result of missed or untreated KD. The disease is most often misdiagnosed or overlooked in infants and teenagers, but it can be missed in young children as well.

Prompt diagnosis and timely treatment are important to prevent complications affecting the heart arteries, according to Dr. Burns. Children are hospitalized and receive an intravenous treatment called gamma globulin, a product containing antibodies that comes from donor blood. The goal is provide the treatment within 10 days of developing the illness.

Uma O'Donnell of Manhasset, Long Island, says when her son Nick came down with Kawasaki Disease at age five, eight doctors failed to make the correct diagnosis. Although it was 10 years ago and her son is now in good health, she says it was a nightmare she and her husband, Vincent, will never forget. "It was horrific for the whole family," she says.

Ms. O'Donnell, trained as a respiratory therapist, says she knew something was terribly wrong with Nick, yet her son's pediatrician at the time refused to take her seriously. Despite Nick's unrelenting fever and numerous symptoms pointing to KD, she says the pediatrician dismissed his illness as a virus that would run its course.

As his symptoms got worse, the family took him to the emergency room connected to a local children's hospital every day for almost a week, where numerous physicians also said he had a virus and sent him home. Finally, Ms. O'Donnell was referred to a Great Neck pediatrician, who made the correct diagnosis. Her son was hospitalized and received the intravenous treatment for KD 10 days after his symptoms began, and he finally started to recover.

More than 5,500 children were hospitalized in the United States for Kawasaki Disease in 2006, the most recent year for which statistics were available from the Centers for Disease Control. But the number is probably higher, according to Dr. Burns, because it does not include all hospitals nationwide and some cases are never diagnosed. Children of all races and ethnicities are affected. Without treatment, about 25 percent of children develop heart disease involving the coronary arteries.

Despite several years of research, the cause of KD remains a mystery. At the moment, there is no specific test, such as a blood test or throat culture, to diagnose it. The doctor makes the diagnosis based on the child's symptoms, in addition to laboratory tests that show inflammation.

The KD Foundation has designed a poster depicting the signs and symptoms of the illness. It is available to doctors' offices, hospitals and clinics upon request. A printable version is also available on the foundation web site.

A wealth of information about Kawasaki Disease, including an information packet and newsletter, is available at

ABOUT THE KAWASAKI DISEASE FOUNDATION - The Kawasaki Disease Foundation is a national nonprofit organization of parents, patients, and medical professionals dedicated to advancing Kawasaki Disease issues. The Foundation focuses on awareness, support, and research in the area of Kawasaki Disease. The Foundation promotes early detection and treatment of Kawasaki Disease, and provides information and support for families through a nationwide telephone and e-mail help network. For more information, visit: